激光生物学报2011，Vol.20Issue(1)：134-142,9.DOI:10.3969/j.issn.1007-7146.2011.01.026
光动力学疗法的单态氧剂量学研究进展
The Research Progress in Singlet Oxygen Dosimetry for Photodynamic Therapy
摘要
Abstract
Singlet oxygen ( 1 O2 ) is believed to be the major cytotoxic species generated during Type-Ⅱ photochemical reaction of photodynamic therapy ( PDT), and the direct detection of 1 O2 luminescence has received considerable attention during the past two decades. The most attractive advantage of this photo-physics-based technique for direct PDT dosimetry is that it can circumvent the complicated interactions between photosensitizer, treatment light and molecular oxygen. It has been previously demonstrated that PDT efficiency is correlated well with cumulative 1 O2 luminescence counts detected during PDT treatment. In this review, the generation of 1O2 during photosensitization and detection techniques of 1O2 luminescence are introduced, and the 1 O2 lifetimes in different solvents are summarized. Furthermore, the most recent advances in PDT-1 O2 dosimetry for in vitro cell model, in vivo animal model, and pre-clinical studies are presented in details. Finally, the challenges and trends in developing PDT-1 O2 dosimetry for clinical application are briefly discnssed.关键词
光动力学疗法/单态氧/剂量学/发光/检测/寿命Key words
photodynamic therapy/ singlet oxygen/ dosimetry/ luminescence/ detection/ lifetime分类
生物科学引用本文复制引用
林慧韫,陈德福,李步洪,谢树森,Huang Zheng..光动力学疗法的单态氧剂量学研究进展[J].激光生物学报,2011,20(1):134-142,9.基金项目
国家自然科学基金项目(60978070 （）
61036014) （）
教育部科学技术研究重点项目(209063)和教育部新世纪优秀人才支持计划(NCET-10-0012) （209063）
