激光生物学报2011，Vol.20Issue(1)：74-77,4.DOI:10.3969/j.issn.1007-7146.2011.01.014
小鼠增龄过程中耳蜗MeCP2的变化
Changes of MeCP2 in the Cochlea of BALB/c Mice during the Aging Process
摘要
Abstract
Based on the previous studies of auditory function measurement and cochlear morphological evaluation in BALB/c mice of different age, the expression and distribution of methyl-CpG-binding protein 2 ( MeCP2 ) in the cochlea of BALB/c mice were identified and compared among four age groups (3-, 6-, 12- and 18-month- old) by the immunohistochemical technique, which threw light on the effects of MeCP2 in the aging process of auditory system.The expression of MeCP2 was detected in the immunohistochemical staining study, predominantly in the cell nuclei.With monthly added age of the mice the positive staining was found to be weaker and the proportion of the positive cells was lower.The decrease of the MeCP2 expression level in the cochlea was correlated with the degree of aging, which indicates that MeCP2 may play an important role in the aging process of auditory system.关键词
老化/耳蜗/免疫组化/MeCP2Key words
aging/ cochlea/ immunohistochemisty/ MeCP2分类
医药卫生引用本文复制引用
蒋腊梅,张勇,葛圣雷,伍伟景..小鼠增龄过程中耳蜗MeCP2的变化[J].激光生物学报,2011,20(1):74-77,4.基金项目
湖南省科技厅科学研究项目(2008FJ3053) （2008FJ3053）
国家自然科学基金项目(30700940) （30700940）
湖南师范大学博士科研启动计划项目(医090628) （医090628）
