动物营养学报2011，Vol.23Issue(3)：521-528,8.DOI:10.3969/j.issn.1006-267x.2011.03.025
蛋氨酸羟基类似物对小鼠营养物质消化和肌肉生长的影响
Effects of Methionine Hydroxy Analogue on Nutrient Digestion and Muscle Growth in Mice
摘要
Abstract
The aim of this research is to observe the effects of methionine ( MET) and its hydroxy analogue 2hydroxy-4-(methythio) butanoic acid ( HMTBA) on the levels of free radicals, the ratio of feed to gain, nutrient digestibility, and muscle growth of mice fed high-fat diet. Sixty KM male mice were randomly divided into 4 dietary groups: control-fat diet with 0. 2％ MET, control-fat diet with 0. 1％ HMTBA and 0. 1％ MET, high-fat diet with 0.2％ MET, and high-fat diet with 0. 2％ HMTBA, respectively. The free radicals, leg muscle proportion and relative expression of related genes were determined after 4 weeks. The results showed that compared with the control-fat diet with 0. 2％ MET group, high-fat diet with 0.2％ MET increased the level of free radicals in whole blood and tissues significantly (P ＜0. 05) and resulted in oxidative stress, but the levels of free radicals of the mice fed high-fat diet with 0. 2％ HMTBA were decreased to the levels close to the control group.Because of the addition of HMTBA, the digestibility of protein and fat of the mice fed high-fat diet were increased significantly ( P ＜0. 05) , and the ratio of feed to gain were decreased significantly ( P ＜0. 05) ; the relative expression yield of the gene of IGF- Ⅰ in liver and jejunum was increased; the leg muscle proportion of the mice and the relative expression yield of gene Myogegin in the muscle were increased, while the relative expression yield of gene My ostatin was decreased significantly ( P ＜0. 05) . In conclusion, appropriate levels of dietary HMTBA can effectively eliminate free radicals in mice fed high-fat diet, reduce the ratio of feed to gain, improve nutrient digestibility, and promote muscle growth and expression yield of positively related genes. [ Chinese Journal of Animal Nutrition ,2011 ,23( 3 ) :521-528 ]关键词
蛋氨酸/蛋氨酸羟基类似物/高脂饲粮/自由基/消化率/肌肉生长分类
农业科技引用本文复制引用
杨永兰,夏淑芳,刘骥,乐国伟,施用晖..蛋氨酸羟基类似物对小鼠营养物质消化和肌肉生长的影响[J].动物营养学报,2011,23(3):521-528,8.基金项目
国家自然科学基金30571347 （）
