中国药房2011，Vol.22Issue(10)：905-907,3.
恩替卡韦初始治疗与接续阿德福韦序贯治疗的抗乙肝病毒疗效观察
Efficacy Observation of Initial Entecavir Therapy vs. Entecavir Sequential Therapy Following Adefovir for HBV
崔速南 1汪明明 1刘春华 2崔海彬 1郭楠1
作者信息
- 1. 济南市传染病医院肝病科,济南市,250021
- 2. 山东聊城市人民医院感染科,聊城市,252000
- 折叠
摘要
Abstract
OBJECTIVE: To observe clinical efficacy of initial entecavir therapy vs.entecavir sequential therapy following adefovir for chronic hepatitis B.METHODS: 63 patients with HBeAg positive chronic hepatitis B were divided into initial group (35 cases) and sequential group (28 cases).Sequential group composed of patients with drug resistance or unfavorable response to adefovir.All patients received entecavir monotherapy(0.5 mg, qd)and liver protectant.Biochemical tests and serum virological parameters were monitored every 1～2 months in 2 groups.RESULTS: The number of patients whose HBV DNA levels maintained at undetectable level in initial group was significantly higher than in sequential group after 6 months of therapy, the proportion at 12th month was 94.3％ (P＜0.05);S/CO value of HBeAg and HBeAb in initial group was significantly lower than in sequential group after 8 months of therapy.3 case of initial group acquired HBeAg/HBeAb seroconversion at 12th month (8.6％) while it wasn't found in sequential group.Biochemical parameter change had no significant difference between 2 groups.All patients achieved biochemical normalization after 6 months of therapy.CONCLUSION: The study suggests that clinical efficacy of initial entecavir therapy is better than entecavir sequential therapy followng adefovir for HBV.关键词
慢性乙型肝炎/恩替卡韦/初始治疗/序贯治疗/抗乙肝病毒分类
医药卫生引用本文复制引用
崔速南,汪明明,刘春华,崔海彬,郭楠..恩替卡韦初始治疗与接续阿德福韦序贯治疗的抗乙肝病毒疗效观察[J].中国药房,2011,22(10):905-907,3.
