中国药房2011，Vol.22Issue(10)：909-911,3.
重组人粒细胞-巨噬细胞集落刺激因子治疗早期糖尿病足溃疡疗效观察
Efficacy Observation of Recombinant Human Granulocyte Macrophage-colony Stimulating Factor for Early Diabetic Foot Ulcers
易吉秀1
作者信息
- 1. 重庆黔江中心医院内分泌科,重庆市,409000
- 折叠
摘要
Abstract
OBJECTIVE: To observe curative efficacy of local subcutaneous injection of recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) in the treatment of early diabetic foot ulcers. METHODS: Blood glucose of 36 patients with diabetic foot ulcers at 1 ～3 levels were controlled ideally by intensive insulin therapy. Surface of the ulcer was disinfected with iodophor and rinsed with normal saline, and necrosis tissues were cleared away. The surface of the ulcer was rinsed with normal saline at the second time. Then they were divided into 2 groups randomly. Treatment group: rhGM-CSF was subcutaneous injected directly around the ulcer at dose of 5 μg·kg-1· -d-1 once a day. Control group: the surface of ulcer was disinfected regularly and covered with an asepsis vaseline earbasus, the dressing was changed once a day. Both groups lasted for 30 days. RESULTS:The total effective rates of treatment group and control group were 100.0％ and 83.3％ (P＜0.05). Average admission days were 21 days and 32 days(P＜0.05). CONCLUSION: Overall response rate of diabetic foot ulcers at 1～3 levels and the healing of chronic wound of diabetic foot have been improved by local subcutaneous injection of rhGM-CSF.关键词
糖尿病足/重组人粒细胞-巨噬细胞集落刺激因子/治疗分类
医药卫生引用本文复制引用
易吉秀..重组人粒细胞-巨噬细胞集落刺激因子治疗早期糖尿病足溃疡疗效观察[J].中国药房,2011,22(10):909-911,3.
