同济大学学报（医学版）2011，Vol.32Issue(1)：51-55,60,6.DOI:10.3969/j.issn1008-0392.2011.01.051
Ghrelin在反流性食管炎患者胃底组织中的表达
Expression of Ghrelin in fundus of stomach in patients with reflux esophagitis
吴萍 1许树长 2孔炫 3刘远飞2
作者信息
- 1. 同济大学附属同济医院临床营养科,上海,200065
- 2. 同济大学附属同济医院消化内科,上海,200065
- 3. 上海市杨浦区中心医院消化内科,上海,200433
- 折叠
摘要
Abstract
Objective To study the relationship between Ghrelin and reflux esophagitis ( RE) by detecting the quantity of Ghrelin in gastric mucosa.Methods Included in this study were twenty gastroenterology outpatients diagnosed RE from Aug.to Nov.2009 by endoscopy inspection according to Los Angeles endoscopy standard were.Their body mass indexes( BMI) were between 18.5 kg/m2and 23.9 kg/m2 , and their Helicobacter pylori ( Hp) were negative by the rapid urease test.Among them fourteen patients were A grade and six patients were B grade .Twenty healthy subjects whose gender composition,age and BMI matched with the RE group served as controls with negative Hp too.Gastro-duodenal endoscopy was performed with all subjects drawn a mucosa in the stomach antrum and the relative quantity of Ghrelin measured then by Real-Time fluorescence quantitative polymerase chain reaction.Results of RE and control groups and the results of A and B grade groups were compared.Results The relative quantity of Ghrelin in the mucosa with RE was significantly lower than that in healthy controls( P ＜ 0.05 ) ,while Ghrelin had no statistical difference between A and B grade patients ( P ＞ 0.05 ) .Conclusion Ghrelin precipitats the transient lower esophageal sphincter relaxations and increases the gastro-esophageal acid exposure.Hence it may play a role in the pathogenesis of RE.关键词
反流性食管炎/Ghrelin/实时荧光定量PCR分类
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吴萍,许树长,孔炫,刘远飞..Ghrelin在反流性食管炎患者胃底组织中的表达[J].同济大学学报（医学版）,2011,32(1):51-55,60,6.
