疑难病杂志2011，Vol.10Issue(1)：21-22,2.DOI:10.3969/j.issn.167-6450.2011.01.009
舒洛地特联合贝那普利治疗糖尿病肾病临床观察
Therapeutic effects of sulodexide combined with benazapril on patients with diabetic kidney disease
摘要
Abstract
Objective To investigate the effects of combination therapy of sulodexide and benazapril in patients with diabetic kidney disease ( DKD ).Methods Forty-five patients with DKD were randomly divided into control group ( n= 22 ) and treatment group ( n=23 ).The control group was treated with benazapril, and the treatment group received the combination therapy of benazapril and sulodexide.After 8 weeks, fasting blood glucose ( FBG ),24h urine protein, fibrinogen ( FIB ),urine β2-microglobulin ( β2 -MG ) and fructosamine were measured and compared between the two groups.Results The value of FBG didn' t changed obviously in the two groups.Compared with pre-treatment, the levels of 24h urine protein were decreased in both of the two groups.FIB was decreased only in treatment group.Compared with control group, the levels of 24h urine protein, FIB, β2-MG and fructosamine were decreased in treatment group( P ＜ 0.05, P ＜ 0.01 ).Conclusion Sulodexide combined with benazapril can improve renal function in patients with DKD.关键词
舒洛地特/贝那普利/24 h尿蛋白定量/纤维蛋白原/尿β2-微球蛋白/糖尿病肾病引用本文复制引用
刘珊..舒洛地特联合贝那普利治疗糖尿病肾病临床观察[J].疑难病杂志,2011,10(1):21-22,2.
