疑难病杂志2011，Vol.10Issue(1)：19-20,2.DOI:10.3969/j.issn.1671-6450.2011.01.008
单唾液酸四己糖神经节苷脂联合高压氧治疗一氧化碳中毒迟发性脑病临床研究
Clinical study on monosialotetrahexosyl ganglioside combined with hyperbaric oxygen in the treatment of delayed encephalopathy after carbon monoxide poisoning
司玲珍 1职慧苗 1付慧丹1
作者信息
- 1. 471023,河南洛阳钢铁集团有限责任公司职工医院
- 折叠
摘要
Abstract
Objective To investigate the effect of monosialotetrahexosyl ganglioside ( GM1 ) combined with hyperba ric oxygen in the treatment of delayed encephalopathy after carbon monoxide poisoning ( DEACMP ). Methods 41 cases with DEACMP were randomly divided into therapy group ( 21 cases ) and control group ( 20 cases ). The basic treatment of two groups was hyperbaric oxygen, and then therapy group was treated with GM1 injection 100 mg/d which lasted 14 days, then 40 mg/d which lasted 16 days. The changes of MMSE were measured in two groups before and after treatment, and clinical effect were assessed. Results The score of MMSE improved obviously after treatment in both of the two groups ( P ＜ 0.01 ),and there was a significant difference between the two groups ( P ＜0.01 ). The total effective rate was 90.5％ in treatment group, and 70.0％ in control group, the different between therapy group and control group was significant ( P ＜ 0.05 ). Conclusion The treatment of GM1 combined with hyperbaric oxygen has favorable effect on DEACMP, which can be used extensively.关键词
一氧化碳中毒/脑病,迟发性/高压氧/单唾液酸四己糖神经节苷脂引用本文复制引用
司玲珍,职慧苗,付慧丹..单唾液酸四己糖神经节苷脂联合高压氧治疗一氧化碳中毒迟发性脑病临床研究[J].疑难病杂志,2011,10(1):19-20,2.
