中国全科医学2011，Vol.14Issue(5)：547-549,3.
文拉法辛联合马来酸曲美布汀及双歧三联活菌治疗难治性肠易激综合征的疗效观察
Therapeutic Effect of Venlafaxine and Trimebutine and Bifidobiogen on Refractory Irritable Bowel Syndrome
陈叶青 1周国华 1周红宇 1王为 1刘树旗 1王丽姣1
作者信息
- 1. 421002湖南省衡阳市,中国人民解放军169医院消化内科
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effect of venlafaxine and trimehutine and bifidohiogen on refractory irritable bowel svndrome. Methods 80 patients with refractory IBS were randomly divided into control group and treatment group , with each 40 patients. Patients in control group received conventional treatment ( trimehutine and bifidobiogen ). Patients in treatment group received venlafaxine. 5 - hydroxytryptamine in addition to all the conventional treatments in control group.The course of treatment was 12 weeks. Before and after treatment all patients were graded with symptom severity and symptom frequency , as well as with Hamilton anxiety scale and Hamilton depression scale. Results ( 1 ) Digestive tract symptom: symptom seriousness exponent and symptom frequency exponent of treatment group were significantly lower than those of control group ( P ＜0. 01 ). ( 2 ) Curative effect: the effective rate of treatment group was 92. 5％ . and control group was 70. 0 ％ . the difference was significant ( P ＜ 0. 05 ). ( 3 ) Hamilton anxiety scale and Hamilton depression scale in treatment group were significantly lower than those in control group ( P ＜0. 05 ). ( 4 ) Side effects of medicine: dizziness, hypodynamia. nausea, constipation were frequently shown in treatment group in the first week . and they disappeared after 1 ～ 2 week. Conclusion Most refractory IBS patients are with anxiety and depression disturhance. Antidepressants combined with trimebutine and hifidobiogen can significantly improve somatic and mental symptom . and it is safe and effective.关键词
肠易激综合征/抗抑郁药/治疗结果分类
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陈叶青,周国华,周红宇,王为,刘树旗,王丽姣..文拉法辛联合马来酸曲美布汀及双歧三联活菌治疗难治性肠易激综合征的疗效观察[J].中国全科医学,2011,14(5):547-549,3.
