中国病理生理杂志2011，Vol.27Issue(1)：196-199,4.DOI:10.3969/j.issn.1000-4718.2011.01.039
内质网应激与prion疾病
Endoplasmic reticulum stress and prion diseases
徐琨 1楚雍烈2
作者信息
- 1. 西安交通大学医学院免疫与病原生物学系,分子病毒研究所,陕西,西安,710061
- 2. 中国疾病预防控制中心病毒病预防控制所,传染病预防控制国家重点实验室,北京,100052
- 折叠
摘要
Abstract
Endoplasmic reticulum ( ER ), as an important cellular organelle in eukaryotic cells, is destroyed and dysfunctional under harmful stimuli.The stimuli cause the ER stress response which even induces the cell apoptosis.Recent studies indicate that ER stress is closely related to the occurrence and development of the neurodegenerative disease, for instance , prion diseases.The pathogenic agent known as misfolded prion protein causes the imbalance of ER homeostasis and then induces the neuron apoptosis.This review will summarize the latest research progress of the relationship between ER stress and prion diseases.关键词
内质网/内质网应激/朊病毒病/细胞凋亡分类
医药卫生引用本文复制引用
徐琨,楚雍烈..内质网应激与prion疾病[J].中国病理生理杂志,2011,27(1):196-199,4.
