中国中西医结合杂志2011，Vol.31Issue(3)：338-341,4.
失眠患者血清甲状腺激素及多巴胺水平与中医证型的关系
Correlation between Serum Thyroid Hormone and Dopamine Levels and Chinese Medicine Syndrome Types
摘要
Abstract
Objective To analyze the correlation between changes of thyroid hormone (TH), dopamine (DA) and Chinese medicine syndrome types by detecting contents of serum TH and DA in insomnia, thus to explore objective indices of Chinese medicine syndrome types. Methods Insomnia patients were assigned to four Chinese medicine syndrome types groups, covering depressed Gan transforming into fire, internal disturbance by phlegm-heat, excessive fire due to yin deficiency, and Xin-Pi deficiency. One healthy control group was set up.Each group consisted of 30 patients or subjects. Serum DA content was determined using spectrophotofluorimetry. Serum levels of 3,5,3′-triiodothyronine (T3) and tetraiodothyronine (T4) were detected using radioimmunoassay (RIA). Results The serum leuels of DA and TH showed difference among groups at various levels. The serum DA level was sequenced from high to low as the control group ＞ the depressed Gan transforming into fire group ＞ the excessive fire due to yin deficiency group ＞ the internal disturbance by phlegm-heat group ＞ the Xin-Pi deficiency group. The serum TH level was sequenced from high to low as the excessive fire due to yin deficiency group ＞ the depressed Gan transforming into fire group ＞ the internal disturbance by phlegm-heat group ＞ the control group ＞ the Xin-Pi deficiency group. Conclusions Serum DA levels in insomnia patients were in line with the disease course and the dynamic change from sthenia to asthenia in Chinese syndrome types. Serum DA levels,as one of pathological factors constituting the sthenia syndrome or the asthenia syndrome, may be taken as an objective indicator in Chinese medicine syndrome typing.关键词
失眠/多巴胺/甲状腺激素/中医证型引用本文复制引用
黄俊山,樊建锋,刘芳,曾雪爱,钟静瑜..失眠患者血清甲状腺激素及多巴胺水平与中医证型的关系[J].中国中西医结合杂志,2011,31(3):338-341,4.基金项目
福建省中西医结合老年性疾病重点实验室开放课题及陈可冀中西医结合发展基金资助(No.2008J1004-22,CKJ2008059) （No.2008J1004-22,CKJ2008059）
福建省中医药科研项目重点课题(No.wzzs0901) （No.wzzs0901）
