中国中西医结合杂志2011，Vol.31Issue(3)：407-412,6.
鱼腥草注射液临床不合理用药不良事件分析
Analysis of Adverse Events Caused by Irrational Application of Houttuynia Injection
崔小花 1卞兆祥 2王莉 1成岚 1袁强 1李廷谦 3李幼平 1邓绍林 3商洪才 4张伯礼4
作者信息
- 1. 四川大学华西医院中国循证医学中心,成都,610041
- 2. 香港浸会大学
- 3. 四川大学华西医院,成都,610041
- 4. 天津中医药大学,天津,300193
- 折叠
摘要
Abstract
Objective To analyze irrational clinical application of Houttuynia Injection (HI) and the risk of adverse event (AE) occurrence, thus providing references for after-sales reevaluation and rational clinical application of HI. Methods Literatures concerning unreasonable application of HI were searched (terminated by June 2010) from PubMed, EMBASE, Chinese Biomedical Disc (CBMdisc), Chinese National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Full-text Database (VIP), and etc. for case report,cross-sectional study, and clinical control study. Results A total of 342 papers with a total of 416 AE cases were retrieved. Of them, AE happened to 294 cases ( including 290 children) of the 132 papers concerning contraindications, and 48 with allergic shock; AE happened to 57 cases in 9 papers reporting over-dose, and 6 with high risk combined medication. Sixteen irrational administration ways were reported in 195 papers. Of them, AE happened to 59 cases of seven administration ways ( twenty cases by intracavitary injection, thirteen by aerosol inhalation, ten by rinse, eight by oral administration, one by enema, one by acupoint injection, and one by rectal administering). AE was not reported in the rest ten reports. Conclusion The risk of AE occurrence was increased by changing clinical administration ways of HI without authorization, over-dose medication, high risk combined medication, and application in people with contraindications.关键词
鱼腥草注射液/不合理用药/不良事件/风险引用本文复制引用
崔小花,卞兆祥,王莉,成岚,袁强,李廷谦,李幼平,邓绍林,商洪才,张伯礼..鱼腥草注射液临床不合理用药不良事件分析[J].中国中西医结合杂志,2011,31(3):407-412,6.
