临床与实验病理学杂志2011，Vol.27Issue(1)：71-74,78,5.
子宫内膜样腺癌中mTOR和eIF4E蛋白表达及临床意义
Expression of mTOR and eIF4E and their clinical implications in endometrial endometrioid adenocarcinoa
康丽菲 1李月红 2张祥宏 2吴文新 2马毓梅 2张杰英2
作者信息
- 1. 河北省胸科医院病理科,石家庄,050041
- 2. 河北医科大学第二附属医院病理科,石家庄,050000
- 折叠
摘要
Abstract
Purpose To detect the expression of mTOR. eIF4E in endometrial endometrioid adenocarcinoma and endometrial intraepithelial neoplasia ( EIN ) and to explore the role of mTOR and eIF4E in the endometrial endometrioid carcinogenesis. Methods The expression of mTOR and eIF4E protein was detected in 17 cases of proliferative endometrium, 64 proliferative lesions and 44 endometrioid adenocarcinomas with immnohistochemical staining. Results No case of mTOR strong staining was found in proliferative endometrium and simple endometrial hyperplasia cases. In complex hyperplasia and endometrioid adenocarcinoma cases, the strong expression rates of mTOR were 23. 40％ and 52. 27％ , respectively, which was significantly higher than that in other groups ( P ＜ 0. 05 ). The strong expression rates of mTOR in endometrioid adenocarcinoma was significantly higher than that in complex hyperplasia and complex hyperplasia with atypical hyperplasia ( P ＜ 0. 05 ). The strong expression of mTOR was closely related with differentiation of tumor in endometrioid adenocarcinoma. The strong positive expression rate in grades Ⅱ andⅢ cases was significantly higher than that in grade Ⅰ ( 72. 41％ vs 13. 33％ , P ＜ 0. 05 ). No significant correlation was found between the expression of mTOR ancl TNM stage and lymph node metastasis in endometriod adenocarcinoma ( P ＞ 0. 05 ). The positive expression rates of eIF4E in proliferative endometrium, simple endometrial hyperplasia, complex hyperplasia and endometrioid adenocarcinoma were 52. 94％ ,73. 68％ ,85. 11％ and 90. 91％,respectively. The rates of eIF4E in complex hyperplasia and endometrioid adenocarcmoma were significantly higher than that in the other groups ( P ＜ 0. 05 ), but no significant difference was found between complex hyperplasia and endometrioid adenocarcinoma( P ＞0. 05 ). No association was found between the expression of eIF4E and TNM stage, pathological grade as well as lymph node metastasis ( P＞0. 05 ). Conclusions The up-regulation expression of mTOR and eIF4E may be involved in the carcinogenesis of endometriod adenocarcinoma.关键词
子宫内膜样腺癌/mTOR/eIF4E/非典型增生分类
医药卫生引用本文复制引用
康丽菲,李月红,张祥宏,吴文新,马毓梅,张杰英..子宫内膜样腺癌中mTOR和eIF4E蛋白表达及临床意义[J].临床与实验病理学杂志,2011,27(1):71-74,78,5.
