临床与实验病理学杂志2011，Vol.27Issue(1)：19-21,3.
乳腺癌组织中LVD、VEGF-C和MMP-9表达及其相关性
Expression of VEGF-C, MMP-9 and lymphatic vessel density in breast carcinoma and their correlation
摘要
Abstract
Purpose To investigate the relationship between lymphatic vessel density ( LVD ) and the expression of VEGF-C and MMP-9 in hreast cancer. Methods 80 cases of breast invasive ductal carcinoma and 20 cases of breast proliferative lesions were collected. The expressions of LYVE-1 , VEGF-C and MMP-9 were investigated using the PV-6000 immunohistochemical methods. Results LVD,VEGF-C and MMP-9 in hreast carcinoma were obviously higher than that in the breast proliferative lesions ( P ＜ 0. 01 ). No significant difference was ohserved between LVD and VEGF-C expression with tumor size, tumor grade and lymphatic metastasis status ( P ＞0. 05 ). There was positive association between LVD and VEGF-C ( r = 0. 398,P ＜ 0. 01 ). MMP-9 expression was higher in the tumor size ＞ 2 cm group and lymphatic metastasis positive group ( P ＜ 0. 05 and P ＜ 0. 01 ) . hut unrelated to tumor grades ( P ＞0. 05 ).No significant differenc:e was observed between MMP-9 and LVD ( P ＞ 0. 05 ). Conclusions LVD in invasive ductal carcinoma is in a high level. VEGF-C promotes the lymphangiogenesis, which is an important stimulating factor for lymphangiogenesis. However, LVD may be not associated with lymphatic metastasis. In addition, MMP-9 may play an important role in the invasion and lymphatic metastasis in breast cancer.关键词
乳腺肿瘤/LYVE-1/VEGF-C/MMP-9/淋巴结转移分类
医药卫生引用本文复制引用
韩玉贞,张志强,桑晶,吴淑华..乳腺癌组织中LVD、VEGF-C和MMP-9表达及其相关性[J].临床与实验病理学杂志,2011,27(1):19-21,3.基金项目
山东省医药卫生科技发展计划资助项目(2009HZ001) （2009HZ001）
