中国全科医学2011，Vol.14Issue(5)：491-493,3.
吉西他滨联合奥沙利铂序贯放疗治疗体力状况评分为2分的局部晚期非小细胞肺癌的疗效研究
Sequential Chemoradiation of Gemcitabine with Oxaliplatin for Locally Advanced Non-small Cell Lung Cancer
王建芳 1孙彩萍 1陈遐林 1叶万立1
作者信息
- 1. 312000,浙江省绍兴市人民医院肿瘤放疗科
- 折叠
摘要
Abstract
Objective To evaluate the short - term curative effect of Gemcitabine plus oxaliplatin ( Gemox protocol ) radiotherapy ( RT ) on advanced non - small cell lung cancer ( NSCLC ) and its toxic and side effects. Methods Sixty - six NSCLC patients ( physical score = 2 ) were divided randomly into groups Gemox + RT ( n =34 ) and GP ( gemcitabine plus cispla-tin protocol ) + RT ( n = 32 ). Patients received a total dose ( TD ) of 60 - 66 Gy RT after 2 cycles of chemotherapy, and 4 cycles after radiotherapy. Results No significant difference was noted in short - term effect between 2 groups ( P ＞ 0. 05 ). The 1 -year survival rates of groups Gemox + RT and GP + RT were 50. 5％ , 61. 2％ , respectively, and median survival time was 13 -14 months, the difference was not significant ( P ＞0. 05 ). The incidences of radiation pneumonia ( 5. 9％ ) and radiation esoph-agitis ≥Ⅲ ( 8. 8％ ) of Gemox + RT group were not significantly different from those of GP + RT group ( P ＞0. 05 ). Incidences of leukocyte reduction and thrombocytopenia were lower in Gemox + RT group ( 32. 3％ , 20. 6％ , respectively ) than in GP + RT group ( P ＜0. 05 ). Conclusion Gemox sequential chemo - and radio - therapy, having higher tolerance than GP protocol and similar efficacy, is an effective treatment for NSCLC.关键词
癌,非小细胞/吉西他滨/奥沙利铂/顺铂/抗肿瘤联合化疗方案分类
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王建芳,孙彩萍,陈遐林,叶万立..吉西他滨联合奥沙利铂序贯放疗治疗体力状况评分为2分的局部晚期非小细胞肺癌的疗效研究[J].中国全科医学,2011,14(5):491-493,3.
