中国中西医结合杂志2011，Vol.31Issue(3)：315-318,4.
高脂血症血瘀证患者血浆可溶性CD40配体水平及其临床意义
Changes of Soluble CD40 Ligand in Patients with Hyperlipidemia of Blood Stasis Syndrome and Its Clinical Significance
金露 1何立人 1符德玉 1邓中龙1
作者信息
- 1. 上海中医药大学附属岳阳中西医结合医院心血管内科,上海,200437
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摘要
Abstract
Objective To observe changes of soluble CD40 ligand (sCD40L) in patients with hyperlipidemia of blood stasis syndrome and its correlation with blood stasis syndrome integral, P-selectin, and high sensitive creatine reactive protein ( hs-CRP), to investigate the roles of platelet activation and inflammation in the physiopathologic process of blood-stasis type hyperlipidemia, and to explore the pathogenetic mechanism of blood-stasis syndrome (BSS). Methods Seventy hyperlipidemia patients were assigned to two groups, 39 in the BSS group and 31 in the non-BSS group. Meanwhile, thirty healthy subjects were grouped as the control. Main physiochemical indices, blood levels of sCD40L, P-selectin, hs-CRP were detected in all. The correlations of the aforesaid indices were analyzed. Results BSS score in the BSS group was higher than that in the non-BSS group and in the control group. Higher blood levels of P-selectin and sCD40L were shown in the BSS group than in the non-BSS group [ (25. 13 ±5.49) ng/L vs (21.37 ±3. 56) ng/L and (2. 45 ±0. 48) ng/L vs (2. 07 ± 0. 41 ) ng/L] respectively, and the two indices were higher in hyperlipidemia patients than in healthy persons [ (14. 91 ±2. 48) ng/L and (1.63 ±0. 25) ng/L, P＜0. 01 ]. Correlation analysis showed that in patients with hyperlipidemia, blood level of sCD40L was positively correlated with low-density lipoprotein cholesterol (LDL-C) level (r=0. 503, P ＜0. 01 ), P-selectin ( r=0. 897, P＜0. 01 ), and the BSS score ( r=0. 603, P＜0. 01 ). Conclusions The over-expressed sCD40L indicated persistent inflammatory state in patients with hyperlipidemia of BSS. BSS would further accelarate the chronic inflammation process of hyperlipidemia.关键词
高脂血症/血瘀证/可溶性CD40配体/炎症引用本文复制引用
金露,何立人,符德玉,邓中龙..高脂血症血瘀证患者血浆可溶性CD40配体水平及其临床意义[J].中国中西医结合杂志,2011,31(3):315-318,4.
