中德临床肿瘤学杂志（英文版）2011，Vol.10Issue(3)：125-133,9.DOI:10.1007/s10330-011-0740-8
上皮间质转化与恶性肿瘤转移
Epithelial-mesenchymal transition and cancermetastasis
摘要
Abstract
Epithelial-mesenchymal transition (EMT) is initially considered as a physiological phenomenon during the embryogenesis of mammals,as well as a basic biological event maintaining the stability of the vital body.Recent researches indicated that EMT plays a critical role in various tumors progression,through which epithelial cancers invade and metastasize.The cell characteristics are changed during EMT,in which the cells lose cell-cell and cell-matrix interactions and apical polarity,reorganize their cytoskeleton,and become isolated,motile,as well as resistant to anoikis,then become spindle-shaped mesenchymal cells.This review lays emphasis on studying the cell morphogenesis,makers and molecular mechanism regulation about EMT,discussing the relationship between the EMT and the cancer development and metastasis.关键词
EMT/molecular mechanism/cancer/metastasisKey words
EMT/molecular mechanism/cancer/metastasis引用本文复制引用
Junjian Deng,Ximing Xu..上皮间质转化与恶性肿瘤转移[J].中德临床肿瘤学杂志（英文版）,2011,10(3):125-133,9.基金项目
Supported by the grants from the Natural Science Foundation of China (No.81000998) and Natural Science Foundation of Hubei Province of China (No.2007ABA248). （No.81000998）
