重庆医学2011，Vol.40Issue(7)：644-645,649,3.DOI:10.3969/j.issn.1671-8348.2011.07.008
35例多发性硬化患者Th17细胞及相关细胞因子的检测
Detection of Thl7 cells and related cytokines in 35 cases of multiple sclerosis
于周 1吕志宇 2李作孝2
作者信息
- 1. 四川省凉山彝族自治州第一人民医院神经内科,西昌,615000
- 2. 泸州医学院附属医院神经内科,四川泸州,645000
- 折叠
摘要
Abstract
Objective To invcstigate the levels of T help 17 cells(Th17) and related cytokines in the patients with multiple sclerosis(MS) and their significance to clinic. Methods IL-17 and IL-23 levels for multiple sclerosis patients and controls were evalua ted by enzyme-linked immunoassay. The frequencies of Th17 in CD4+T cells were checked by flow cytometic analysis. Results The frcqucncies of Th17 in peripheral blood were found to be significantly higher in the patients with multiple sclerosis(P＜0. 01). Th17 type cytokine IL-17 and IL-23 markedly incrcased in multiple sclerosis patients[IL-17 : MS( 69. 01± 19. 29) ng/L , control( 25. 94± 15. 61) ng/L] ; IL-23 : MS( 550. 80± 112. 06) ng/L , control(158. 78 ± 33. 19) ng/L , ( P ＜ 0. 01). Plasma concentration of IL-17 was positively corelated with concentration of IL-23 in multiple sclerosis patients(r=0. 731, (P＜O. 01). Conclusion The frcquencies of Th17 cells and Thl7 type cytokines in the patients with multiple sclerosis may suggest a potential role in progression and stability of multiple sclerosis.关键词
多发性硬化/白细胞介素/Th17细胞引用本文复制引用
于周,吕志宇,李作孝..35例多发性硬化患者Th17细胞及相关细胞因子的检测[J].重庆医学,2011,40(7):644-645,649,3.
