重庆医学2011，Vol.40Issue(8)：739-741,3.DOI:10.3969/j.issn.1671-8348.2011.08.005
依帕司他治疗糖尿病周围神经病变疗效的Meta分析
Treating diabetic peripheral neuropathy with epalrestat:a Meta-analysis
摘要
Abstract
Objective To evaluate the therapeutic effect of epalrestat on diabetic peripheral neuropathy(DNP). Methods The odds ratio of symptom improving between the treatment and control groups was analyzed. Related published literatures on effect of epalresta on DPN were fully searched and screened through computed database. The data were extracted for summarizing all the studies,calculating the pooled OR and its 95％ confidence interval(95％CI) , and testing the overall effects by RevMan5. 0. Both publication bias analysis and sensitivity analysis were performed for evaluating the reliability and stability of the meta-analysis. Other indexes in the literatures which were not adapted for meta-analysis were also described. Results 10 literatures,totally 805 cases, were obtained. Some heterogeneity were discovered between the studies(P=0. 07). Epalresta may significantly relieve the symptom of patients with diabetic peripheral neuropathy. Its OR and 95％C1 was 8. 08(5. 04 -12. 94 ,P＜0. 000 01). The results of sensitivity analysis and publication bias analysis accounted for the reliability and two studies had publication bias of this meta-analysis. Epalrestat also played an role in raising nerve conduction velocity and reducing blood viscosity according to the results of the literatures. Conclusion Epalresta can effectively relieve DPN symptoms,improve the relative laboratorv indexes. It is a better method for DPN treatment.关键词
糖尿病神经病变/Meta分析/依帕司他引用本文复制引用
杨拯,王燕,张晓,陈建敏..依帕司他治疗糖尿病周围神经病变疗效的Meta分析[J].重庆医学,2011,40(8):739-741,3.基金项目
成都医学院综合设计性实验项目基金资助项目(ZH2010009). （ZH2010009）
