医药导报2011，Vol.30Issue(3)：317-319,3.DOI:10.3870/yydb.2011.03.017
奥卡西平与碳酸锂治疗躁狂发作的疗效比较
Efficacy Comparison Between Oxcarbazepine and Lithium Carbonate for Manic Episode
马永春 1王鹤秋 1金卫东 1王乃信1
作者信息
- 1. 浙江省立同德医院精神科,杭州,310012
- 折叠
摘要
Abstract
Objective To assess the efficacy and safety of oxcarbazepine and lithiun carbonate for treating manic episode.Methods 70 patients with manic episode were randomly divided into oxcarbazepine group (n= 34 ) and lithium carbonate group ( n= 36 ).The patients in oxcarbazepine group were treated with 0.6-1.8 g· d -1 oxcarbazepine, and those in lithium carbonate group were treated with 0.5-1.5 g· d -1 lithium carbonate, on the base of atypical antipsychotics therapy.All patients were assessed by Beck-Rafaelsen manic scale ( BRMS ) for 6 weeks.Results BRMS in two groups significantly decreased after treatment for 6 weeks (P＜0.01).BRMS of oxcarbazepine group was significantly lower than tha of lithium carbonate group a the end of 1st and 2nd week after treatment (P＜0.05).The efficacy rate of oxcarbazepine group and full remission rate after treatment were significantly higher than those in the lithium carbonate group (P＜0.05).Similar side effects was found between two groups (P＞0.05).Conclusion Combinaion of oxearbazepine and atypical antipsychotics are more effective than lithium carbonate and safe.关键词
奥卡西平/碳酸锂/躁狂发作分类
医药卫生引用本文复制引用
马永春,王鹤秋,金卫东,王乃信..奥卡西平与碳酸锂治疗躁狂发作的疗效比较[J].医药导报,2011,30(3):317-319,3.
