医药导报2011，Vol.30Issue(3)：306-309,4.DOI:10.3870/yydb.2011.03.012
晚期非小细胞肺癌患者培美曲塞化疗后血清肿瘤标志物变化与疗效的相关性
Correlation Between Tumor Markers Variance and Chemotherapeutic Effect of Pemetrexed on Patients with Advanced Non-small Cell Lung Cancer
王增 1翁琳 1游隽 1程斌1
作者信息
- 1. 浙江省肿瘤医院药剂科,杭州,310022
- 折叠
摘要
Abstract
Objective To investigate the changes of serum levels of tumor markers during chemotherapy of single pemetrexed or combination with platinum in patients with advanced non -small cell lung cancer ( NSCLC ).Methods 102 advanced NSCLC patients who experienced more than 2 cycles of chemotherapy by pemetrexed single agent or combination with platinum were retrospective analyzed.The changes of CEA, CA125, CYFRA21-1, NSE, SCC and changes of chest CT scan were recorded before and after chemotherapy.Results After chemotherapy, tumor markers like CEA, CA125, CYFRA21-1 , NSE and SCC were decreased, in which CEA, CA125 and CYFRA21-1 diminished 19.3％ ( P＜0.05), 24.8％ ( P＜0.05), and 18.5％ (P＜0.05) , respectively.It was suggested that the correlation between tumor marker response (TMR)and imaging-based response ( IBR ) of CEA and CA125 was positive; the correlation between TMR and IBR of CYFRA 21 -1 was also positive; that between TMR and IBR of CEA, CA125 and CA19-9 joint inspection was positive as well.Conclusion Serum CEA, CA125 and CYFRA21-1 represent reliable markers for chemotherapy efficacy on patients with advanced NSCLC.Monitoring changes of serum levels of tumor markers would benefit for assessment of chemotherapy efficacy , which is simple, economic and useful in clinical settings.关键词
培美曲塞/肿瘤标志物/癌,非小细胞肺,晚期分类
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王增,翁琳,游隽,程斌..晚期非小细胞肺癌患者培美曲塞化疗后血清肿瘤标志物变化与疗效的相关性[J].医药导报,2011,30(3):306-309,4.
