军医进修学院学报2011，Vol.32Issue(1)：39-40,55,3.
IOLP方案治疗急性淋巴细胞白血病的疗效观察
Efficacy of IOLP regimen on acute lymphoblastic leukemia
王志红 1达万明 2吴晓雄 1马健 1曹永彬 1徐丽昕 1吴亚妹 1闫蓓 1刘周阳 1高春记2
作者信息
- 1. 解放军总医院304临床部,血液科,北京,100048
- 2. 解放军总医院,血液科,北京,100853
- 折叠
摘要
Abstract
Objective To study the efficacy of IOLP regimen on acute lymphoblastic leukemia(ALL) and its safety. Methods Thirteen patients with ALL were treated with IOLP regimen to observe its efficacy on ALL, recovery time of white blood cells(WBC) and platelets(PLT), and its hematological toxicity. Results Of the 13 patients after one course of treatment, 10(76.9%) had complete remission(CR), 2(15.4%) had partial remission(PR) and 1(7.7%) had no remission(NR). Of the 13 patients after two courses of treatment, 12(92.3%) had CR, 1(7.7%) had PR, 1(7.7%) had NR. The median time for WBC and PLT to increase to 1.0 × 109/L and 20 × 109/L was 17d and 20.5d, respectively. The minimum median number of WBC and PLT was 0.35 × 109/L and 15×109/L, respectively. Infection occurred in 9 patients(69.2%). The non-hematological toxicologica] reactions included mild digestive canal response, transit elevation of transaminase, incidental abnormal heart function, and elevation of BUN. Conclusion The IOLP regimen is significantly effective against ALL with a high remission rate for risk cases and a lower non-hematological toxicity.关键词
前体细胞淋巴母细胞白血病淋巴瘤/抗肿瘤联合化疗方案/IOLPKey words
Precursor Cell Lymphoblastic Leukemia-Lymphoma/ Antineoplastic Combined Chemotherapy Protocols/ IOLP分类
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王志红,达万明,吴晓雄,马健,曹永彬,徐丽昕,吴亚妹,闫蓓,刘周阳,高春记..IOLP方案治疗急性淋巴细胞白血病的疗效观察[J].军医进修学院学报,2011,32(1):39-40,55,3.
