安徽医科大学学报2011，Vol.46Issue(4)：352-354,3.
微粒体环氧化物水解酶基因Tyr113His多态性与安徽妇女多囊卵巢综合征的相关性
Relationship between gene polymorphism of Tyr113His in microsomal epoxide hydrolase and polycystic ovary syndrome in Anhui women
摘要
Abstract
Objective To investigate the relationship between the microsomal epoxide hydrolase( EPHX )gene Tyr113His polymorphism and polycystic ovary syndrome( PCOS ) in Anhui region. Methods Polymerase chain reaction-restriction fragment length polymorphism( PCR-RFLP ) was preformed to detect the distribution of Tyr113His genotype and allele frequency in EPHX from 636 PCOS patients and 299 healthy controls. Results There was no significant difference in genotype distributions of Tyr113His in EPHX gene between two groups( x2 = 2. 428, df = 2,P = 0. 297 ), no significant difference was found in the distribution of single point allele between two groups( x2 =3. 069 ,df =2,P =0. 216 ). However,we found the statistical difference( x2 =7. 410,df =2,P =0. 025 ) in comparison of genetype distribution between two groups when subdevided the PCOS patients into two groups: non- and obase. Conclusion The variant genotypes of Tyr113His polymorphism in EPHX is not a risk factor for PCOS, but the PCOS patients with low activity of His113His may enhance the incidence of obase for the individuals with PCOS.关键词
多囊卵巢综合征/遗传学/多态现象,遗传Key words
polycystic ovary syndrome/genetics/polymorphism,genetic分类
医药卫生引用本文复制引用
杨露,曹云霞..微粒体环氧化物水解酶基因Tyr113His多态性与安徽妇女多囊卵巢综合征的相关性[J].安徽医科大学学报,2011,46(4):352-354,3.基金项目
国家自然科学基金(编号:30571954) （编号:30571954）
