安徽医科大学学报2011，Vol.46Issue(4)：337-341,5.
缺氧诱导因子-1α与上皮型钙黏素在肝癌中的表达及其意义
Expression of HIF-1α and E-cadherin in hepatocellular carcinoma and their clinical significance
摘要
Abstract
Objective To investigate the expression of hypoxia-inducible factor 1 alpha ( HIF-1α ) and E-cadherin, analyze their correlations and clinical significance in hepatocellular carcinoma ( HCC ) cases. Methods The expression profiles of HIF-1α and E-cadherin were detected on 100 cases HCC clinical samples and 10 normal liver tissues by immunohistochemical staining method , and their correlations with clinicopathological parameters were analyzed. The expression of HIF-1α and E-cadherin in HCC cells with different metastatic potentials was examined by Western blot method. Results HIF-1α expression was positive in 80％ HCC patients, which was associated with TNM stage , invasion and metastasis ( P = 0. 002 ;P = 0. 018 ); however. 520％ HCC showed E-cadherin expression reduced , its expression was also associated closely with invasion and metastasis( P = 0. 001 ). In HCC , HIF-1α expression was negatively correlated with E-cadherin expression ( P =0. 000 ). Western blot analysis showed that the HIF-1α expression in highly metastatic HCC cells was significantly higher than that in lowly metastatic HCC cells.Whereas E-cadherin expression was lower in highly metastatic HCC cells. Conclusion Abnormal HIF-1α and Ecadherin expressions are associated with HCC progression and metastasis; HIF-1α and E-cadherin expression can serve as important markers for judgment of HCC metastasis potency.关键词
癌,肝细胞/缺氧诱导因子1/肿瘤转移分类
医药卫生引用本文复制引用
张传海,许戈良,荚卫东,李建生,马金良,任维华,葛勇胜,王伟..缺氧诱导因子-1α与上皮型钙黏素在肝癌中的表达及其意义[J].安徽医科大学学报,2011,46(4):337-341,5.基金项目
国家自然科学基金(编号:30972893) （编号:30972893）
