中德临床肿瘤学杂志（英文版）2011，Vol.10Issue(3)：162-165,4.DOI:10.1007/s10330-011-0760-4
胃癌组织中HER2基因状态与p21蛋白表达的关系研究
HER2 gene status and the relationship with p21 protein expression in gastric cancer
Yongjie Li 1Yangkun Wang 2Xianwei Zhang 2Fulin Li 2Nianlong Meng 2Xutao Yuan 2Jinsheng Song2
作者信息
- 1. Henan Province People's Hospital of Ruyang County,Ruyang 471200,China
- 2. Department of Laboratory,The 150 Centre Hospital of Chinese PLA,Luoyang 471031,China
- 折叠
摘要
Abstract
Objective:We aimed to analysis the HER2 gene status and its relationship with p21 protein expression in gastric carcinoma.Methods:Fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) techniques were used to detect HER2 gene status and p53 protein in 59 cases of gastric cancer.Results:FISH detection of HER2 gene amplification rate was 16.9% (10/59),HER2 gene amplification in 49 cases without copy number gain and gene amplification were a total of 49.2% (29/59).HER2 protein expression was 42.4% (25/59),HER2 gene amplification rates in patients with +++,++ HER2 protein expression were 3/3 and 5/8,while in patients with + HER2 protein expression,it was 2/14,there was significant difference (P < 0.05).p21 protein expression rate was 49.2% (29/59),HER2 gene amplification rates and p21 protein expression had significant difference in tumor invasion depth,lymph node metastasis (P < 0.05);had no statistical significance in histological type,age,gender differences (P > 0.05).Conclusion:HER2 gene amplification rate and gene copy number had positively correlation with p21 protein expression,HER2 gene status and expression of p21 protein combined detection can provide a reference value in gastric cancer metastasis,patient's condition development and prognosis,it also can guide clinical development of individual treatment.关键词
stomach cancer/HER2 gene/p21 protein expressionKey words
stomach cancer/HER2 gene/p21 protein expression引用本文复制引用
Yongjie Li,Yangkun Wang,Xianwei Zhang,Fulin Li,Nianlong Meng,Xutao Yuan,Jinsheng Song..胃癌组织中HER2基因状态与p21蛋白表达的关系研究[J].中德临床肿瘤学杂志（英文版）,2011,10(3):162-165,4.
