中德临床肿瘤学杂志（英文版）2011，Vol.10Issue(3)：174-177,4.DOI:10.1007/s10330-011-0749-z
骨肉瘤CT灌注成像与血管生成的关系
Application of CT perfusion imaging in detection of tumor angiogenesis in osteosarcoma
摘要
Abstract
Objective:The aim of the study was to explore the application of 64-slice spiral computed tomography perfusion imaging (CTPI) in evaluating angiogenesis in human osteosarcoma.Methods:Twenty-six patients (18 males and 8 females ranging from 9 to 56 years old,with an average of 19 years) with osteosarcoma underwent 64-slice spiral CTPI.We analyzed the correlations of CTPI parameters including blood flow (BF),blood volume (BV),time to peak (TTP),and permeability surface (PS) with the expression of markers of angiogenesis.Statistical analysis was performed with paired-samples t test,and Pearson correlation analysis was employed to investigate the correlations of CTPI parameters with microvessel density (MVD).Results:Mean BF,BV,TTP,and PS values of osteosarcoma group were (46.6 ± 25.1) mL/100 g/min,(61.8 ± 29.5) mL/100 g,(122.9 ± 26.2) seconds,and (44.5 ± 14.6) mL/100 g/min,respectively.Those in the normal muscle group were (5.2 ± 6.6) mL/100 g/min,(9.6 ± 7.3) mL/100 g,(115.5 ± 33.1) seconds and (17.0 ± 29.3) mL/100 g/min,respectively.Osteosarcoma group showed higher BF,BV and PS compared with the normal muscle group (P = 0.000,P = 0.000,and P = 0.000,respectively).However,no significant difference was found in TTP between osteosarcoma tissue and normal adjacent muscle tissue (P = 0.273).BF,BV,and PS were positively correlated with MVD (r = 0.83,P = 0.000;r = 0.87,P = 0.000;and r = 0.63,P = 0.001,respectively).No correlation was found between TTP and MVD (r = –0.02,P = 0.93).Conclusion:CTPI is useful for assessing tumor vascularity of osteosarcoma and CTPI parameters are positively correlated with MVD.关键词
tomography/X-ray computed/osteosarcoma/perfusion/angiogenesisKey words
tomography/X-ray computed/osteosarcoma/perfusion/angiogenesis引用本文复制引用
Xin Shi,Xing Zhou,Sujia Wu,Jiyang Jin,Zhiping Zhou..骨肉瘤CT灌注成像与血管生成的关系[J].中德临床肿瘤学杂志（英文版）,2011,10(3):174-177,4.基金项目
Supported by a grant from the Medical Research Program Foundation for Talents of "Tenth five" of PLA (No.04J002). （No.04J002）
