临床误诊误治2011，Vol.24Issue(3)：22-24,3.
超短期辛伐他汀强化治疗对非ST段抬高型急性冠状动脉综合征患者冠状动脉介入治疗术后的影响
The Effects of Short-Term Treatment with Simvastatin in Patients with non ST-Segment Elevation Acute Coronary Syndrome after Percutanous Coronary Intervention
丁超 1李俊峡 1赵玉英 1张莉 1卫亚丽 1汝磊生1
作者信息
- 1. 050082,石家庄,解放军白求恩国际和平医院心血管内科
- 折叠
摘要
Abstract
Objective To evaluate the effect of no-reflow and prognosis of short-term treatment with large dose of Simvastain in non ST-segment elevation acute coronary syndrome (NSTE-ACS) patients who underwent successful primary percutanous coronary intervention (PCI). Methods 128 patients with NSTE-ACS undergoing PC1 during 72 h after hospitalization were selected and randomly divided into normal group and intensive group, with 64 cases in each group. Both groups received oral Simvastatin for 3 days before PCI (80 mg/d in normal group, 20 mg/d in intensive group). The status of no-reflow and MACE was observed. Results The incidence of no-reflow in intensive group was significantly lower than that in normal group (3.1％ vs 12. 5％ ,x2 =3. 9, P ＜0. 05), and the incidence of MACE in intensive group was also lower than that in normal group 1 moth after treatment ( 1.6％ vs 10.9％ ,x2 =4. 8, P ＜0. 05). Conclusion Short-term treatment with high-dose of Simvastatin in NSTE-ACS patients before PCI could improve myocardial blood peffusion, and reduce the incidence of no-reflow and MACE.关键词
辛伐他汀/急性冠状动脉综合征/经皮冠状动脉介入术Key words
Simvastatin/ Acute coronary syndrome/ Percutanous coronary intervention分类
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丁超,李俊峡,赵玉英,张莉,卫亚丽,汝磊生..超短期辛伐他汀强化治疗对非ST段抬高型急性冠状动脉综合征患者冠状动脉介入治疗术后的影响[J].临床误诊误治,2011,24(3):22-24,3.
