中国药房2011，Vol.22Issue(1)：27-28,2.
长期口服卡托普利对小鼠脑组织自由基及相关酶的影响
Effect of Long-term Oral Dose of Captopril on Free Radicals and Related Enzymes of Mice Cerebral Tissue
谢湘林 1马春颖 1周鸣 2叶秋芳 1赵莉 1刘宏雁1
作者信息
- 1. 吉林大学药学院药理教研室,长春市,130021
- 2. 长春中医药大学第一附属医院新药中心,长春市,130021
- 折叠
摘要
Abstract
OBJECTIVE: To explore the effect of long-term oral dose of Captopril on free radicals and related enzymes of mice cerebral tissue in order to give experimental basis for clinical use of captopril. METHoDS: 30 normal adult mice were divided into control group (water) and captopril group (captopril 11.08～14.92 mg·kg-1·d-1). Both groups were given medicine for 14 weeks.Free radicals and the activity of related enzymes (MDA, SOD, GSH-Px, Na+-K+-ATP enzyme, Ca2+-Mg2+-ATP enzyme) in cerebral tissue were detected. RESULTS: Compared with control group, in captopril group the content of MDA decreased (P＜0.05), the activity of SOD, GSH-Px hadn' t changed obviously. The activity of Ca2+-Mg2+-ATP enzyme and Na+-K+-ATP enzyme declined, but there was no statistical significance. CONCLUSION: Oral does of captopril for a long time can reduce free radicals and strengthen the antioxidant function of cerebral tissue, but it may damage the neuron membrane function of cerebral tissue.关键词
卡托普利/自由基/小鼠/丙二醛/超氧化物歧化酶/谷胱甘肽过氧化物酶/钠-钾泵三磷酸腺苷酶/钙-镁泵三磷酸腺苷酶分类
医药卫生引用本文复制引用
谢湘林,马春颖,周鸣,叶秋芳,赵莉,刘宏雁..长期口服卡托普利对小鼠脑组织自由基及相关酶的影响[J].中国药房,2011,22(1):27-28,2.
