临床与实验病理学杂志2011，Vol.27Issue(3)：289-292,4.
亚低温对大鼠缺血性脑损伤后JAK1-STAT1通路的作用
Effect of mild hypothermia on JAK1-STAT1 pathway after focal cerebral ischemia and reperfusion
徐玉婷 1柳红 2赵瑞波1
作者信息
- 1. 徐州医学院病理学教研室,徐州,221002
- 2. 哈尔滨医科大学病理学教研室,哈尔滨,150086
- 折叠
摘要
Abstract
Purpose To observe the expression of JAK1 and STAT1 protein and the change induced by administration of local mild hypothermia after focal cerehral ischemia, and to further investigate the neuroprotective mechanism of mild hypothermia on ischemia brain injury. Methods A focal cerehral ischemia and reperfusion model was established by an intraluminal filament embolism of the middle cerebral artery. The rats in the experimental group were treated by mild hypothermia. Pathological changes were observed with hematoxylin and eosin stain. The expression of JAK1 and STAT1 was detected by immunohistochemical staining. The expression of STAT1 protein was also detected with Western blot. Results Compared with the sham - operation group, the expression of JAK1 and STAT1 began increased at 6th hour and reached the peak at 24th hour in normal ischemic group. The expression in the mild hypothermia ischemic: group was obviously decreased than that in normal ischemic group ( P ＜ 0. 05 ). Conclusions JAK1-STAT1 pathway is activated after focal cerebral ischemia and reperfusion. and mild hypothermia can partially alleviate the apoptosis of neuron after ischemia/reperfusion by inhibiting the expression of JAK1 and STAT1.关键词
脑缺血再灌注/亚低温/蛋白酪氨酸激酶1/信号转导子和转录激活子1分类
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徐玉婷,柳红,赵瑞波..亚低温对大鼠缺血性脑损伤后JAK1-STAT1通路的作用[J].临床与实验病理学杂志,2011,27(3):289-292,4.
