中国药房2011，Vol.22Issue(1)：10-12,3.
纳米喜树碱的蛋白结合率及其在血清中的稳定性研究
Protein Binding Rate of Nano-camptothecin with Albumin and Its Stability in Serum
摘要
Abstract
OBJECTIVE: To investigate the binding rate of nano-camptothecin in different species of protein and the stability of it in different species of serum. METHODS: HPLC method was used to detect the binding rate of nano-camptothecin in human albumin (AHS) and bovine albumin (ABV) and the stability of it in mice serum, bovine serum, human serum and phosphate solution.RESULTS: The binding rate of nano-camptothecin was (38.089 2 ± 2.903 4)％ in ABV and (27.330 5 ± 4.261 8) ％ in AHS. The concentration of nano-camptothecin in human serum and bovine serum were higher than in phosphate solution and mice serum.CONCLUSION: Species of protein and serum are the key influencing factors of the stability of nano-camptothecin.关键词
纳米喜树碱/白蛋白/血清/稳定性/小鼠/小牛分类
医药卫生引用本文复制引用
苏琳,刘晨,李庆勇,邓晓秋,高洋,赵修华,祖元刚..纳米喜树碱的蛋白结合率及其在血清中的稳定性研究[J].中国药房,2011,22(1):10-12,3.基金项目
国家自然科学基金(30600052) （30600052）
2006新世纪优秀人才项目(NCET-06-0329) （NCET-06-0329）
黑龙江省留学回国人员科技项目择优资助基金优秀项目 （）
林业科学技术研究项目(2007-12) （2007-12）
黑龙江省科技计划项目(QC08C30) （QC08C30）
中央高校基本科研业务费专项基金项目(DL09DAQ02)和东北林业大学研究生论文资助项目 （DL09DAQ02）
