临床与实验病理学杂志2011，Vol.27Issue(3)：234-238,5.
肝脏上皮样血管内皮瘤临床病理观察
Clincopathologic study on hepatic epithelioid hemangioendothelioma
陈骏 1丁洁 2贾支俊 3吴鸿雁 1孟凡青1
作者信息
- 1. 南京大学医学院附属鼓楼医院,病理科,南京,210008
- 2. 南京大学医学院附属口腔医院病理科,南京,210008
- 3. 南京大学医学院附属鼓楼医院,核医学科,南京,210008
- 折叠
摘要
Abstract
Purpose To investigate the clinico-pathological characteristics and differential diagnosis of hepatic epithelioid hemangioen dothelioma( EHE ). Methods The clinical manifestations, pathological features. immunohistochemistry, treatment and prognosis were analyzed in 3 cases of hepatic EHE with the review of literatures. Results All three cases occur in women with 70. 75 and 36 years old, respectively. It is multifocal in 2 cases, and the other has single tumor in the liver. The classical pattern demonstrates cords of ovoid epithelioid or spindled cells with dense and hyalinized fibrous tissue. The cells tend to form lumina within individual cells and between cells, mimicking signet-ring cells. Blood cells may occasionally be found in the lumina. At its margin the tumor tends to infiltrate hepatic sinusoids and small vessels. Immunohistochemically, the tumor cells were positive for vimentin. factor Ⅶ. CD34, CD31 and D2-40 , but negative for CK.CK7 .CK8/18 .Hep-1 .AFP. Conclusion Hepatic EHE is a rare tumor and its outcome is variable.Some patients have died with a rapidclinical course. D240 would be useful as a diagnostic marker for EHE in liver tumors.关键词
肝肿瘤/上皮样血管内皮瘤/免疫组织化学/病理/鉴别诊断分类
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陈骏,丁洁,贾支俊,吴鸿雁,孟凡青..肝脏上皮样血管内皮瘤临床病理观察[J].临床与实验病理学杂志,2011,27(3):234-238,5.
