肿瘤预防与治疗2011，Vol.24Issue(2)：79-82,4.DOI:10.3969/j.issn.1674-0904.2011.02.004
晚期非小细胞肺癌患者HER-2蛋白表达及其临床意义
Expression and Clinical Significance of HER-2/neu in Patients with Advanced Non-small Cell Lung Cancer
任庆 1宋向群2
作者信息
- 1. 解放军第181中心医院,肿瘤治疗中心,广西,桂林,541002
- 2. 广西医科大学附属肿瘤医院化疗科,南宁,530021
- 折叠
摘要
Abstract
Objective : To test the expression of HER-2 protein in patients with advanced non-small cell lung cancer and investigate the relationship between HER-2 protein expression and chemotherapy, survival rate. Methods : 58 paraffin-embedded tumor samples from patients with non-small cell lung cancer were examined for HER-2 protein expression by immunohistochemical methods ( MaxvisionTM quick immunohistochemical methods ). Results : Positive expression of HER-2 protein in total 58 patients was 25. 9％.The response rate to chemotherapy in positive and negative HER-2 protein expression group was 33. 3％ and 65. 1％ respectively( P = 0. 03 ). The survival difference was not significant between the positive and negative HER-2 protein expression group( P = 0. 13 ).Conclusion : HER-2 protein can be used as an independent predict factor for the sensitivity of chemotherapy. The correlation between overexpression of HER-2 protein and prognosis of advanced non-small cell lung cancer should be further studied.关键词
非小细胞肺癌/HER-2/化疗/预后分类
医药卫生引用本文复制引用
任庆,宋向群..晚期非小细胞肺癌患者HER-2蛋白表达及其临床意义 [J].肿瘤预防与治疗,2011,24(2):79-82,4.
