山西医科大学学报2011，Vol.42Issue(3)：233-236,4.DOI:10.3969/J.ISSN.1007-6611.2011.03.016
子宫颈鳞状细胞癌中SCCA1和SCCA2的表达及意义
Expression of SCCA1 and SCCA2 in cervical squamous cell carcinoma and its clinical significance
摘要
Abstract
Objective To investigate the expression of squamous cell carcinoma antigen( SCCA )1 and SCCA2 mRNA in cervical squamous cell carcinoma, and to explore its significance in the clinical diagnosis,and the evaluation of efficacy and prognosis. Methods Quantitative real time PCR was used to detect the expression of SCCA1 and SCCA2 mRNA in 60 cases of cervical squamous cell carcinoma and 30 cases of normal cervical tissues. Results The expression level of SCCA2 mRNA in cervical squamous cell carcinoma was higher than those in normal cervical tissues( P ＜0.001 ),while the expression level of SCCA1 mRNA showed no significant difference between normal and malignant tissues( P ＞ 0.05 ). The expression of SCCA2 mRNA increased as FIGO stage got worse( P ＜ 0.001 ). Moreover, the expression of SCCA2 mRNA was significantly correlated with lymph node metastases( P ＜ 0.05 ), but not with age and pathological grading( P ＞0.05 ). However, the expression of SCCA1 mRNA was not correlated with age,FIGO stages,lymph node metastases and histological grade( P ＞ 0.05 ). Conclusion The expression of SCCA2 mRNA may provide more accurate information for diagnosing the clinical stages and lymph node metastases of cervical squamous cell carcinoma.关键词
宫颈鳞癌/SCCA1/SCCA2/实时PCR分类
医药卫生引用本文复制引用
闫丽隽,赵欣,邵淑丽..子宫颈鳞状细胞癌中SCCA1和SCCA2的表达及意义 [J].山西医科大学学报,2011,42(3):233-236,4.
