中国组织工程研究与临床康复2011，Vol.15Issue(8)：1413-1416,4.DOI:10.3969/j.issn.1673-8225.2011.08.020
含纳米银壳聚糖/聚乙烯醇抗菌敷料的制备和性能
Preparation and properties of chitosan/polyvinyl alcohol loaded with nano-silver for wound dressing
摘要
Abstract
BACKGROUND: Antiseptic dressing is one of the important measures to prevent occurrence of invasive wound infection, but the long-term use of antibiotics can cause bacteria resistance. Meanwhile, antibacterial materials are combined with cotton fabric to obtain antiseptic d ressing, poor biocompatibility, and should not be used for long-term coverage of wound.OBJECTIVE: To prepare a good biocompatible, antibacterial anti-inflammatory of new antibacterial biological dressing, and to initially detect its biological properties.METHODS: In the study, Ag/SiO2 nanocomposite was synthesized in an absorption phase nanoreactor formed in the ethanol/water/NaOH solution; SiO2 powder loaded with silver was added into chitosan/polyvinyl alcohol reaction solution,chitosan/polyvinyl alcohol sponge containing Ag/SiO2 nanoparticles was prepared by acetalization reaction. The mechanical properties, surface topography, cytotoxicity and antibacterial properties of materials were detected.RESULTS AND CONCLUSION: The material displayed porous structure, and had favorable moisture-adsorption rate, air permeability rate, moisture-retention rate, and high tensile strength; porosity of material was high, interspace of sponge was dense and uniform, the pore diameter was about 0.1-1 mm. The cytotoxicity test using MTT method suggested that the material had no significant cytotoxicity to fibroblasts of mouse and could promote the growth of fibroblasts. Materials on the staphylococcus aureus, escherichia coli, candida albicans, pseudomonas aeruginosa, salmonella typhi had a good bactericidal effect. These results indicated that the material not only possesses good mechanical properties, bioactivity and antibacterial activity, but also its synthesis procedure is simple. Therefore, the developed material can be applied for wound dressing.关键词
纳米银/壳聚糖/聚乙烯醇/抗菌/敷料分类
医药卫生引用本文复制引用
曾晓峰,魏坤,韩雪,罗云,舒丽君,吴远,沈征宇..含纳米银壳聚糖/聚乙烯醇抗菌敷料的制备和性能[J].中国组织工程研究与临床康复,2011,15(8):1413-1416,4.基金项目
由国家863计划(2007AA021908)、国家863计划(2007AA021906) 、国家自然科学基金资助项目(50732003 U0834003)提供资助. （2007AA021908）
