中国组织工程研究与临床康复2011，Vol.15Issue(7)：1259-1263,5.DOI:10.3969/j.issn.1673-8225.2011.07.027
组织工程椎间盘纤维环的研究与进展
Research and progress of tissue-engineered annulus fibrosus disci intervertebralis
摘要
Abstract
BACKGROUND: Tissue engineering is a new strategy that can permanently repair degenerated intervertebral disc. However,nucleus pulposus tissue engineering method cannot completely reconstruct the structure and function of intervertebral discs.Therefore, the corresponding anulus fibrosus tissue engineering is regarded as one of the major limiting factors for the treatment strategies of tissue-engineered interve rtebral disc.OBJECTIVE: To sum up the research and progress of tissue-engineered annulus fibrosus disci intervertebralis, and to provide theoretical foundation of tissue-engineered intervertebral disc.METHODS: Pubmed database, CNKI database, and VIP database from 2000 to 2010 was retrieved by the first author with the key words of "tissue engineering, intervertebral disc, annulus fibrosus, seed cell, scaffold, growth factor" in Chinese and in English,respectively. Literatures were limited to Chinese and English languages. Seed cell source, the selection of scaffold materials, and growth factor of annulus fibrosus disci intervertebralis tissue engineering were summarized.RESULTS AND CONCLUSION: A total of 106 literatures were obtained from computer screen, 34 of them were involved for summarization according to inclusion and exclusion criteria. At present the studies were concentrated on the construction of annulus fibrosus and nucleus pulposus tissues. And the construction of functional annulus fibrosus is still at the initial stage. The selection of the seed cells, scaffold materials and growth factors are still to be further studied.关键词
椎间盘/纤维环/种子细胞/支架材料/生长因子/组织工程分类
医药卫生引用本文复制引用
闫中胜,徐宝山,杨强,夏群,贺坚..组织工程椎间盘纤维环的研究与进展[J].中国组织工程研究与临床康复,2011,15(7):1259-1263,5.基金项目
人力资源和社会保障部留学回国人员科技择优资助项目 （）
天津市卫生局科技攻关项目(07KG1),天津市卫生局科技基金重点资助项目(2010KR08). （07KG1）
