中国组织工程研究与临床康复2011，Vol.15Issue(9)：1611-1614,4.DOI:10.3969/j.issn.1673-8225.2011.09.022
磁共振动态增强扫描成年山羊腰椎髓核:定量观察椎间盘的强化程度及营养状态
Dynamic contrast-enhanced scanning of nucleus pulposus of adult goat: Quantitative observation of enhancement degree and nutrition state of intervertebral discs
摘要
Abstract
BACKGROUND: The reduction of nutrient substances has been considered to be the main factor, which leads to the ultimate way to disc degeneration. Numerous studies have shown that nutrition of intervertebral disc is mainly obtained through endplate ,and there is close relationship between the cataplasia of endplate and that of intervertebral disc. Dynamic contrast-enhanced MRI scans as a non-invasive, repeatable method that has been used to study nutrition mechanism disc.OBJECTIVE: To quantitatively analyze the characteristics of enhancement of nucleus pulpous of adult goat lumbar discs.METHODS: Eight 24-month-old goats, weighing 38 kg and 50 kg, were selected, a total of 32 lumbar inter-vertebral discs were included. After anesthesia for goats, we observed the signal changes of regions of interest by using T1 -TSE-SPIR,T2WI-TSE-SPAIR and dynamic enhanced magnetic resonance scan. On the point of time before enhancement and O minute, 5 minutes, 10 minutes, 30 minutes, 1 hour, 1 .5 hours, 2 hours, 2.5 hours, 3 hours, 3.5 hours and 4 hours after enhancement, the enhancement of nucleus pulposus was calculated and the time-enhancement ratio curve was used to analyze the perfusion characteristics.RESULTS AND CONCLUSION: The nucleus pulposus exhibited no obvious increase within 10 minutes and began to increase quickly at 30 minutes and achieved its peak enhancement at 3.5 hours, after which was the plateau stage. The time-enhancement ratio curve of nucleus pulposus is distinctive, which encourages more researches to explore the mechanism of nutrition.关键词
髓核/山羊/磁共振成像/动态增强/椎间盘退变分类
医药卫生引用本文复制引用
杜恒,管民,麻少辉,韩博,杨广夫,张明,刘淼..磁共振动态增强扫描成年山羊腰椎髓核:定量观察椎间盘的强化程度及营养状态[J].中国组织工程研究与临床康复,2011,15(9):1611-1614,4.基金项目
陕西省2007年科技计划项目(2007k14-1)"建立阻断双侧椎体终板营养途径的新型动物模型" （2007k14-1）
