中国组织工程研究与临床康复2011，Vol.15Issue(7)：1281-1284,4.DOI:10.3969/j.issn.1673-8225.2011.07.032
周围神经损伤修复与再生中的基因治疗
Gene therapy in the repair and regeneration of peripheral nerve injury
李璟寰 1田京2
作者信息
- 1. 南方医科大学第二临床医学院,广东省广州市,510282
- 2. 南方医科大学附属珠江医院骨科中心,广东省广州市,510282
- 折叠
摘要
Abstract
BACKGROUND: Functional recovery of peripheral nerve after repair is not ideal. Gene therapy provides a new method for repair peripheral nerve injury.OBJECTIVE: The paper reviewed from three areas, including functional gene, transfer vector selection, and biological effects of gene translation factors, aimed to provide reference for gene therapy for peripheral nerve injury.METHODS: A computer-based online search of PubMed and CNKI between 2006 and 2010 was performed to search related articles with the key words of "peripheral nerve injury, gene therapy, virus vector" both in English and Chinese. Literatures related to gene therapy for peripheral nerve injury were selected, in the same field , the articles pu blished lately or pu blished by authoritative Journals were preferred.RESULTS AND CONCLUSION: A total of 35 articles were searched by computer and 21 documents were included after screening. Currently, technology of gene therapy for peripheral nerve injury has matured, such as transgenic adenovirus bone morphogenetic protein 7 and Ad-32Ep65-Flag gene, the clinical repair of peripheral nerve is expected to become an important means.关键词
周围神经损伤/基因治疗/病毒载体/基因翻译因子/修复分类
医药卫生引用本文复制引用
李璟寰,田京..周围神经损伤修复与再生中的基因治疗[J].中国组织工程研究与临床康复,2011,15(7):1281-1284,4.
