中国组织工程研究与临床康复2011，Vol.15Issue(8)：1381-1384,4.DOI:10.3969/j.issn.1673-8225.2011.08.012
盐酸替利定在Amberlite IRP-69上的静态离子交换特性
Static ion exchange characteristics of tilidine hydrochloride onto Amberlite IRP-69
丁始安 1李楠 1邓岚 1魏佳 1邓盛齐1
作者信息
- 1. 四川抗菌素工业研究所,四川省成都市610000
- 折叠
摘要
Abstract
BACKGROUND: Molecular structu re of ion exchange resin contains activated groups which can be ionized, it can react with ionic drugs so that the bad smell of drugs is covered up.OBJECTIVE: To study the ion exchange equilibrium characteristics, kinetics and thermodynamics of tilidine hydrochloride onto Amberlite IRP-69.METHODS: The tilidine-resin complex was prepared by batch ion exchange method. The ion exchange equilibrium characteristics and kinetics were determined.RESU LTS AND CONCLUSION : Within the temperature range of 293, 303, 313 K, the exchange-adsorption isothermal equation,the Freundlich equation and the Langmuir equation could give perfect fitting for the ion exchange behavior of tilidine hyd rochloride onto Amberlite IRP-69, the kinetics of ion exchange is a first-order kinetic equation. Thermodynamic parameters of ion-exchange of tilidine hydrochloride onto Amberlite IRP-69 (ΔH ＞ 0, ΔS ＞ 0) indicated that the ion exchange is endothermic, the temperature rise is beneficial for reaction, and entropy increases; free energy change (ΔG ＜ 0) indicated that the reaction is spontaneous. The equilibrium exchange-adsorption of initial concentration of 5 g/L tilidine hyd rochloride on Amberlite IRP-69 was 751 .88 g/L. The drug-resin complex can be prepared at room temperature, by continuous stirring 2 hours using certain concentration of tilidine hydrochloride and certain amount of Amberlite IRP-69 as the carrier, and then to develop related products.关键词
药物树脂/离子交换特性/盐酸替利定/Amberlite IRP-69/生物材料与药物控释分类
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丁始安,李楠,邓岚,魏佳,邓盛齐..盐酸替利定在Amberlite IRP-69上的静态离子交换特性[J].中国组织工程研究与临床康复,2011,15(8):1381-1384,4.
