中国组织工程研究与临床康复2011，Vol.15Issue(7)：1227-1231,5.DOI:10.3969/j.issn.1673-8225.2011.07.019
玉米黄质对高脂诱发鹌鹑模型血管脂质过氧化损伤的保护作用
Protective effect of zeaxanthin on lipid peroxidation injure of blood vessel induced by high lipid in quail model
摘要
Abstract
BACKGROUND:Most synthetic long-term use of antioxidant drugs have certain side effects, zeaxanthin as a natural medicine has its unique physiological effects.OBJECTIVE:To observe the dose-effect relationship of zeaxanthin on lipid peroxidation inju re of blood vessel induced by high lipid in quail hyperlipidmia model.METHODS:Quail hyperipidmia models were established. A total of 40 quails were randomly divided into four groups: control group, model group, zeaxanthin low-dose group and zeaxanthin high-dose group. Seven weeks after gavage using zeaxanthin with 30, 60mg/kg, fasting plasma was harvested to determine serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) level, serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and activity of inducible nitric oxide synthase (iNOS). The TC and TG levels of liver tissue in each group were detected; aortic vascular pathological changes were observed with hematoxylin - eosin staining.RESULTS AND CONCLUSION:Compared with model group,high-dose group of zeaxanthin of the concentration of serum TG,TC, and LDL-C were significantly decreased, while the concentration of serum HDL-C were significantly increased. The synthesis of liver total TG and TC was also strongly inhibited. The activity of glutathione peroxidase and supervxide dismutase were significantly increased, however, the activity of inducible nitric oxide synthase was decreased and MDA level was reduced.Zeaxanthin has a good lipid-lowing effect, and plays a notable inhibitory role in lipid peroxidation injure of blood vessel induced by high lipid. In addition, high-dose of zeaxanthin has better effects than low-dose.关键词
玉米黄质/血管/脂质过氧化损伤/抗氧化/调脂分类
医药卫生引用本文复制引用
李红艳,李丽娅,农林玲,胡春萍,李雷,赖贞红,周志顺,李逊..玉米黄质对高脂诱发鹌鹑模型血管脂质过氧化损伤的保护作用[J].中国组织工程研究与临床康复,2011,15(7):1227-1231,5.基金项目
桂林医学院医药生物技术重点学科立项课题[课题名称:天然抗氧化剂对心血管疾病的防治作用研究] （）
