中国组织工程研究与临床康复2011，Vol.15Issue(8)：1429-1432,4.DOI:10.3969/j.issn.1673-8225.2011.08.024
低频超声波对双氯芬酸钠体外经皮渗透的影响
Effect of low frequency ultrasound on percutaneous absorption of diclofenac sodium in vitro
摘要
Abstract
BACKGROUND: Diclofenac sodium is common used on clinical as a powerful non-steroid anti inflammatory and antalgic drug.Gastrointestinal tract degradation and first-pass effect could be avoided after transdermal delivery. But because of the barrier of skin, transdermal drug delivery is limited. The application of low-frequency ultrasound can promote the drug percutaneous absorption by increasing the permeability of the skin.OBJECTIVE: Based on the study of the influence on percutaneous absorption of diclofenac sodium by low frequency ultrasound,the optimum parameters of diclofenac sodium under low frequency ultrasound were determined.METHODS: Thirty male rats were randomly divided into ten groups, nine of them were used for orthogonal experiment while one for control experiment without ultrasound. The backside skins of rats were selected for transdermal test. The orthogonal experiment was performed in vitro with ultrasonic frequency, intensity and duration as influencing factors, penetration amount as index, and each parameter of low frequency ultrasound was optimized at the optimal permeation effect of diclofenac sodium, and compared with blank group to observe its significance.RESULTS AND CONCLUTION : Ultrasonic intensity, frequency, especially duration had very important influence on the increase in the penetration amount. The optimized parameter combination obtained by orthogonal design was composed of ultrasonic frequency (20 kHz), intensity (0.75 W/cm2) and duration (15 minutes). The frequency, intensity, duration of low frequency ultrasound have a significant effect on the penetration amount of diclofenac sodium (P ＜ 0.01). By the comparison of three parameters, ultrasonic duration is the most important.关键词
低频超声波/经皮渗透/双氯芬酸钠/强度/作用时间分类
医药卫生引用本文复制引用
胡志刚,王新征,冯坤,介晓阳..低频超声波对双氯芬酸钠体外经皮渗透的影响[J].中国组织工程研究与临床康复,2011,15(8):1429-1432,4.基金项目
国家高技术研究发展计划(863计划)(2008AA040208),课题名称:个人卫生护理机器人. （863计划）
