江苏大学学报（医学版）2011，Vol.21Issue(1)：42-45,4.
骨髓增生异常综合征贫血患者Hepcidin的检测意义
Detection of hepcidin in myelodysplastic syndrome patients with anemia and its clinical significance
摘要
Abstract
Objective : To study the relationship of Hepcidin and serum ferritin ( SF) in myelodysplastic syndrome ( MDS) patients with anemia and normal control group , in order to provide the theoretical basis for clinical diagnosis and treatment of iron disorclers related anemia. Methods : EnzymE-Iinkecl immunosorbent assay (ELISA) and radioimmunoassay were used to measure serum Hepcidin of 45 cases of MDS patients with anemia and 60 cases of normal control group , serum ferritin levels were also detected.Results : Hepcidin levels in the normal control group had nothing to clo with age . Hepcidin of male group was significantly higher than that of female group ( P ＜ 0. 01 ) , and there was a strong positive correlation between Hepcidin and SF level ( r ＝0. 895 , P ＜0. 01) . The Hepcidin level of MDS patients was significantly higher than that of control group (P ＜ 0. 01) ; for MDS group, the level of Hepcidin and SF in more than 60-year-old patient group was significantly higher than its level in less than 60-year-old patient group (including 60 years old patients, P ＜0. 01) ; the level of Hepcidin and SF in the group of patients receiving blood transfusion more than three times was significantly higher than that in the patients with blood transfusion less than three times ( including three times , P ＜ 0. 01 ) . Strong positive correlation was found between Hepcidin and SF levels ( r ＝ 0. 983 , P ＜ 0. 01 ) . Conclusion : In physiological circumstances , Hepcidin was mainly regulated by SF , Hepcidin of male was significantly higher than that of females. Hepcidin in patients with MDS was significantly higher than m normal people , and significantly correlated with the number of blood transfusion and age. There was a strong positive correlation between Hepcidin and SF levels in MDS group.关键词
Hepcidin/铁稳态/骨髓增生异常综合征/贫血分类
医药卫生引用本文复制引用
阮舒,秦燕,刘红..骨髓增生异常综合征贫血患者Hepcidin的检测意义[J].江苏大学学报（医学版）,2011,21(1):42-45,4.基金项目
江苏省兴卫工程医学重点人才基金资助(RC2007084) （RC2007084）
江苏省六大人才高峰基金资助 （）
南通大学自然科学研究项目(072090) （072090）
