江苏大学学报（医学版）2011，Vol.21Issue(1)：58-61,封3,5.
保罗样激酶1和p53在食管鳞癌中的表达及临床意义
Clinicopathological significance of PLK1 and p53 expression in esophageal squamous cell carcinoma
殷力佳 1陈德玉 1胡琴1
作者信息
- 1. 江苏大学附属医院放疗科,江苏,镇江,212001
- 折叠
摘要
Abstract
Objective : To detect the expression of PLK1 and p53 proteins in esophageal squamous cell carcinoma ( ESCC ) and to analyze their clinicopathological significance . Methods : The expression of PLK1 and p53 proteins was detected by immunohistochemistry in 87 ESCC specimens , 53 tumor-adjacent dysplastic tissue specimens and 42 normal esophageal mucosa specimens . Statistical analysis was performed using the chi-square test. Results: The positive rates of PLK1 and p53 protein expression differed significantly among ESCC , dysplasia and normal esophageal mucosa ( PLK1 : 57. 5％、50. 9％ and 26. 2％ ; p53 :48. 3％ 、52. 8％ and 23. 8％ ) . The expression of PLK1 and p53 protein was related with ESCC and normal esophageal mucosa ( X2 ＝ 11. 119 and X2 ＝ 7. 047 , all P ＜ 0. 05 ) ; The expression of PLK1 ancl p53 protein was related with dysplasia and normal esophageal mucosa ( X2 ＝5. 982 and X2 ＝ 8. 223 , all P ＜0. 05 ) ; The expression of PLK1 and p53 protein wasn't related with ESCC and dysplasia ( X2 ＝0. 567 and X2 ＝0. 273,all P ＞0. 05 ) . Overexpression of PLK1 and p53 protein was related with lymph node metastasis and TNM stage in ESCC ( all P ＜ 0. 05 ) . PLK1 protein expression was found to be correlated with the depth of tumor invasion ( P ＜0. 01 ) . A negative correlation was also noted between the expression of PLK 1 and that of p53 in ESCC ( r ＝ -0. 286 , P ＜0. 01 ) . Conclusion : Overexpression of PLK1 and p53 proteins is associated with ESCC invasion and metastasis . Combined detection of PLK1 and p53 protein expression is helpful for evaluation of the prognosis of ESCC .关键词
食管鳞状细胞癌/保罗样激酶1(PLK1)/p53/免疫组织化学分类
医药卫生引用本文复制引用
殷力佳,陈德玉,胡琴..保罗样激酶1和p53在食管鳞癌中的表达及临床意义[J].江苏大学学报（医学版）,2011,21(1):58-61,封3,5.
