中国组织工程研究与临床康复2011，Vol.15Issue(6)：1111-1114,4.DOI:10.3969/j.issn.1673-8225.2011.06.036
诱导多潜能干细胞在再生医学中的应用
Application of induced pluripotent stem cells in regenerative medicine
摘要
Abstract
BACKGROUND: Traditional transplantation of organs and cells would induce immunologic rejection and have some problems such as ethics and shortage of donor. Induced plu ripotent stem (iPS) cells have self-renewal ability and differentiational potential as embryonic stem cells, and have genetic materials identical to patients, which avoids immunologic rejection. Thus, its application is broad.OBJECTIVE: To review the current research about the progress of iPS cells in regenerative medicine.METHODS: The PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) was retrieved by computer to search the correlative documents published between 1997 and 2010 with the key words of "induced pluripotent stem cell, diabetes, Parkinson's disease,cardiovascular" in English. Totally 322 papers were primarily gotten. Finally, 30 papers were included.RESULTS AND CONCLUSION: Patient-specific iPS cell is induced from the patients themselves, so that it has the same genetic material and reduces the possibility of immunologic rejection. It also avoids the ethics problem. Thus, iPS cells have very large potential and broad prospect.关键词
诱导多功能干细胞/糖尿病/帕金森病/心肌梗死/再生医学分类
医药卫生引用本文复制引用
刘渔凯,罗虎,李泽桂..诱导多潜能干细胞在再生医学中的应用[J].中国组织工程研究与临床康复,2011,15(6):1111-1114,4.基金项目
第三军医大学创新基金资助项目(2007XG42). （2007XG42）
