中国组织工程研究与临床康复2011，Vol.15Issue(7)：1224-1226,3.DOI:10.3969/j.issn.1673-8225.2011.07.018
膝骨关节炎滑液中可溶性晚期糖基化终末产物受体水平与其病变程度的相关性
Correlation between soluble receptor for advanced glycation end products levels in synovial fluid and disease severity of knee osteoarthritis
李建华 1高巍 2邱南海2
作者信息
- 1. 天津医科大学,天津市,300050
- 2. 天津市海河医院骨科,天津市,300350
- 折叠
摘要
Abstract
BACKGROUND:Studies have demonstrated that soluble receptor for advanced glycation end products (sRAGE) levels in synovial fluid might be negatively associated with disease severity of knee osteoarthritis (OA).OBJECTIVE:To determine the correlation between sRAGE levels in synovial fluid of OApatients and disease severity.METHODS:A total of 46 OA patients and 14 healthy controls were enrolled. The OA was defined using the revised criteria of American Rheumatism Association for the classification of theumatoid arthritis. The disease severity of OA was graded by Kellgren-Lawrence classification. sRAGE levels in synovial fluid were determined by enzyme-linked immunosorbent assay (ELISA).RESULTS AND CONCLUSION:sRAGE levels in synovial fluid were significantly lower in OA patients than in healthy controls (P ＜0.01). sRAGE levels in synovial fluid were negatively associated with disease severity of OA (r=-0.587, P ＜ 0.01). These results demonstrated that sRAGE levels might be associated with the severity and progression of knee OA.关键词
膝/关节/骨关节炎/关节滑液/可溶性晚期糖基化终末产物受体/骨组织工程分类
医药卫生引用本文复制引用
李建华,高巍,邱南海..膝骨关节炎滑液中可溶性晚期糖基化终末产物受体水平与其病变程度的相关性[J].中国组织工程研究与临床康复,2011,15(7):1224-1226,3.
