中国免疫学杂志2011，Vol.27Issue(3)：236-238,3.DOI:10.3969/j.issn.1000-484X.2011.03.010
Drebrin在神经元发育过程中的分布变化
Change of the distribution of drebrin in development of cultured neurons
摘要
Abstract
Objective :To investigate the distribution of drebrin ,an actin-binding protein ,during the development of neurons .Methods : The distribution of drebrin was detected in primary culture of neumns from cerebral cortex by means of immunocytochemistry .Results :The distribution of drebrin was observed in body of the neumns at 1 day in vitro (1 DIV ) .The drebrin was not only in body but also in the processes end and branch of the neumns during 3 and 7 DIV .Lots of puncta of drebrin were observed at the processes of the neurons at 14 and 21 DIV . Conclusion :These results indicate that the distribution of drebrin is translocated from the bodies to the processes following neurons development and mature ,suggesting that there is a close relation among drebrin expression and neurite formation and also ,maturation of dendritic spines during neurons development .关键词
Drebrin/肌动蛋白/神经元/原代培养分类
医药卫生引用本文复制引用
柴继侠,李徽徽,齐琦,周艳梅,刘铜,卓煜娅..Drebrin在神经元发育过程中的分布变化[J].中国免疫学杂志,2011,27(3):236-238,3.基金项目
本文受2010年高校省级优秀青年人才基金资助(No.2010SQRL125) （No.2010SQRL125）
