中国病理生理杂志2011，Vol.27Issue(3)：425-429,5.DOI:10.3969/j.issn.1000-4718.2011.03.002
曲古抑菌素A对心衰大鼠心脏促炎细胞因子及心功能的影响
Effects of trichostatin A on expression of proinflammatory cytokines in hearts and cardiac function in rats with heart failure
摘要
Abstract
AIM: To observe the effects of histone deacetylase inhibitor trichostatin A ( TSA ) on the expression of tumor necrosis factor α ( TNF - α ), interleukin 1 β( IL - 1 β ) and inducible nitric oxide synthase ( iNOS ) in hearts and cardiac function in rats with heart failure( HF ).METHODS : Sprague - Dawley rats were subjected to coronary artery ligation to induce HF, or sham surgery ( sham ).Suhsequently, the animals were treated with TSA or vehicle ( VEH ) for 4 weeks.After 4 weeks, the haemodynamic, the anatomical parameters and the levels of TNF - α, IL - 1β and iNOS in hearts were measured.RESULTS: After treated with TSA, the levels of TNF - α, IL - 1β and iNOS in hearts and left ventricular end - diastolic pressure ( LVEDP ), lung weight/body weight ( LW/BW ) were reduced ( P ＜ 0.05 ) , while +dp/dtmax and - dp/dtmax were increased in heart failure rats ( P ＜ 0.05 ).CONCLUSION : These findings indicate that histone deacetylase inhibitor TSA may improve cardiac function and attenuate pulmonary congestion in rats with HF via inhibiting TNF - α, IL - 1 β and iNOS production in hearts.关键词
组蛋白脱乙酰基酶抑制剂/曲古抑菌素A/心力衰竭/肿瘤坏死因子/白细胞介素/1/一氧化氮合酶分类
医药卫生引用本文复制引用
郭艳琳,张华屏,郭建红,刘育艳,秦达念,王淑秋,杨志明,康玉明..曲古抑菌素A对心衰大鼠心脏促炎细胞因子及心功能的影响[J].中国病理生理杂志,2011,27(3):425-429,5.基金项目
国家自然科学基金资助项目(No.30770867) （No.30770867）
教育部留学回国人员科研启动基金资助项目 （）
国家教育部博士点基金资助项目(No.20070114002) （No.20070114002）
山西省自然科学基金资助项目(No.2010011052-1) （No.2010011052-1）
