中国病理生理杂志2011，Vol.27Issue(3)：616-619,624,5.DOI:10.3969/j.issn.1000-4718.2011.03.040
脓毒症中免疫负调控途径的研究进展
Update on immunological pathway of negative regulation in development of sepsis
摘要
Abstract
Sepsis is not only a primitively systemic inflammatory response to presumed or known infection, but also closely related to the immune status.In the initial stage of sepsis, a phase of immune activation could be evident, but a marked apoptosis - induced depletion of lymphocytes and a series of impairments in nonspecific immunological functions following severe trauma and burns appear to be responsible to the susceptibility of subsequent septic complications.Presently, negative regulation has been shown to play a pivotal role in the maintenance of peripheral homeostasis and regulation of immune responses.Understanding the basic immunological pathway of negative regulation should provide novel insights into the mechanisms of sepsis and immune homeostasis.This review provides a summary of the negative - regulatory pathways that are involved in the pathogenesis of sepsis.关键词
免疫/炎症/负调控/脓毒症分类
医药卫生引用本文复制引用
栾樱译,姚咏明..脓毒症中免疫负调控途径的研究进展[J].中国病理生理杂志,2011,27(3):616-619,624,5.基金项目
国家自然科学基金资助项目(No.30901561) （No.30901561）
国家重点基础研究发展计划资助项目(No.2005CB522602) （No.2005CB522602）
