中国人兽共患病学报2011，Vol.27Issue(3)：196-200,5.
隐孢子虫感染小鼠MHC-Ⅱ类抗原的表达
Expression of major histocompatibility complex-Ⅱ on mouse cryptosporidiosis
摘要
Abstract
To observe the treating function of Fructus Psoraleae and dihydroartemisinin on mouse infected with Cryptosporidiurn parvum and to research the regulating function of major histocompatibility complex- Ⅱ , 60 mice were randomly divided into five groups: normal group A; positive control group- Ⅰ B;one-week treatment group C; positive control group- Ⅱ D; two-week treatment group E. Mice in group B, C, D, and E were injected subcutaneously with dexamethasone. When the mice were infected with C. parvum, they were treated with the medicine respectively. The intestine tissue was observed via HE.The expression of MHC-Ⅱ were observed by immunohistochemistry. The damaged intestine got improved and repaired, and a significant decrease of the amount of C. parvum oocysts in feces was shown in the treated groups (C, E) compared with positive control groups (B, D) (P＜0. 05). In 1-week treatment group, the MHC- Ⅱ expression of group B was higher than that of normal group A. There was no difference between the expression of MHC- Ⅱ in group B and that in group C; in 2-week treatment group, there was no difference between the expression of MHC- Ⅱ in group E and that in group A. The MHC- Ⅱ expression of group D was lower than that of group A and B (P＜0.05). It's suggested that fructus Psoraleae and dihydroartemisinin are effective to treat mouse cryptosporidiosis. The expression of MHC- Ⅱ might be regulated by the mixture.关键词
补骨脂/双氢青蒿素/隐孢子虫/抗原提呈细胞/MHC-Ⅱ类抗原分类
医药卫生引用本文复制引用
秦元华,郑莉莉,戴晓冬,任一鑫,崔昱..隐孢子虫感染小鼠MHC-Ⅱ类抗原的表达[J].中国人兽共患病学报,2011,27(3):196-200,5.基金项目
辽宁省教育厅科学研究计划资助项目部分资金(No.2004D103) （No.2004D103）
