中国人兽共患病学报2011，Vol.27Issue(3)：180-183,4.
人用流感禽流感联合疫苗的研究
Human /avian influenza conjugated vaccines for human use
摘要
Abstract
In this study, the safety of the influenza vaccine conjugated with H5N1 avian influenza vaccine were investigated, and the cross-reaction between the two vaccines were tested.The monovalent-, tervalent- and quadrivalent- influenza vaccines and avian influenza were prepared, rabbits were immunized subsequently, and neutralizing antibodies and haemagglutination inhibition antibodies were further measured.Additionally, these vaccines were used to inoculate mouse and guinea pig, and monitored the toxicity and allergic effects.Our results demonstrated that no cross-reaction was observed using influenza vaccine conjugating with H5N1 avian influenza vaccine, nor toxicity occurred, indicating the potential application of these two conjgated vaccines.关键词
人流感疫苗/H5N1禽流感疫苗/疫苗联合/抗体干扰/安全性分类
医药卫生引用本文复制引用
朱函坪,陈学奎,姚苹苹,徐芳,谢荣辉,杨章女,李岩金,朱智勇..人用流感禽流感联合疫苗的研究[J].中国人兽共患病学报,2011,27(3):180-183,4.基金项目
浙江省重大与高发疾病防治技术专项(2007C13002)资助 （2007C13002）
