中国人兽共患病学报2011，Vol.27Issue(3)：238-240,3.
细粒棘球绦虫(中国大陆株)谷胱甘肽s-转移酶重组蛋白(rEgGST)的免疫保护性研究
Immune protection of recombinant protein Glutathione s-transferase (rEgGST) of Echinococcus granulosus(Chinese mainland strain)
摘要
Abstract
The aim of the present study was to investigate the protective immunity against Echinococcus granulosus and its potential as vaccine candidate by using rEgGST immunizes in mice.ICR mice were randomly divided into the immunized group and the control group, and subcutaneously immunized three times.Mice were infected with protoscolices 4 weeks after immunization and sacrificed 20 weeks after infection to calculate immune protection and examine the levels in serum.Results showed that compared with the adjuvant control group, protein immunized mice's protective immunity was 89.39％.The levels of IgG, IgG's subtypes and IgE increased in varying degrees(P＜0.05).It's suggested that rEgGST could induce some protective immunity, indicating that rEgGST is a promising candidate vaccine against echinococcosis.关键词
细粒棘球蚴/谷胱甘肽s-转移酶/免疫保护力分类
医药卫生引用本文复制引用
高鹏,雄英,杜娟,李居怡,王娅娜,李宗吉,赵巍..细粒棘球绦虫(中国大陆株)谷胱甘肽s-转移酶重组蛋白(rEgGST)的免疫保护性研究[J].中国人兽共患病学报,2011,27(3):238-240,3.基金项目
国家自然科学基金资助项目(No.30260105) （No.30260105）
国家自然科学基金资助项目(No.30660176) （No.30660176）
宁夏自然科学基金资助项目(No.NZ0540) （No.NZ0540）
